Blood Volume and Hemodynamic Analysis in Patients With Chronic Heart Failure

Completed · Not applicable

Conditions studied: Congestive Heart Failure

In brief

The primary hypothesis is that patients with HFREF (heart failure with reduced ejection fraction) will demonstrate a markedly expanded intravascular volume which will correlate with elevated right heart hemodynamics and increased venous capacitance parameters, whereas patients with HFPEF(heart failure with preserved ejection fraction) will demonstrate euvolemia to mild volume expansion and a lack of correlation with hemodynamic and venous compliance parameters.

Key facts

Study ID

NCT02120014

Run by

Mayo Clinic

People needed

60

Starts

2014-04-21

Expected to finish

2018-07-06

Last updated by the study team

2018-10-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age >18 years
• patients identified with heart failure and diagnosed clinically to require right heart hemodynamic evaluation, New York Heart Association functional Class II-IV status/Stage C-D heart failure
• ischemic or nonischemic etiology heart failure
• left ventricular ejection fraction measured within 6 months of study enrollment

You may not qualify if…

• known significant intrinsic chronic kidney disease (baseline Glomerular Filtration Rate <15 ml/min/1.73m²) or patients receiving hemodialysis
• known renal artery stenotic disease
• females who are pregnant
• allergy to iodine contrast, intravenous pyelogram dye, shellfish or eggs.

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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