Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy

Completed · Not applicable

Conditions studied: Tooth Movement

In brief

Currently, orthodontic treatment typically lasts approximately 2 years. There are a number of advantages for reducing the duration of treatment, including reducing the potential risk of caries, root resorption and for minimizing patient "burn out" from prolonged treatment. While some evidence does exist that vibration may accelerate the speed of tooth movement, the biological mechanism is still unknown. Identification of specific factors involved in tooth movement that are further stimulated by vibration would help to understand the mechanisms involved as well as discover possible biologic targets which could be utilized or modified to maximize the benefits of vibration treatment. The purpose of this study is to identify novel biological factors that are expressed in patients undergoing orthodontic tooth movement in conjunction with vibration appliance therapy.

Key facts

Study ID

NCT02119455

Run by

UConn Health

People needed

40

Starts

2014-04-01

Expected to finish

2018-06-01

Last updated by the study team

2019-12-13

Who can join

Age: 15 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy, non-smoker with no systemic medical conditions and no routine medications
• 15 to 35 years of age at the time of bonding
• Non-extraction treatment plan or no extractions required in the first 6 months of treatment
• At least 5mm of crowding in the mandibular arch
• Full-complement dentition 1st molar to 1st molar
• Good oral hygiene

You may not qualify if…

• Patients that require extractions as part of the orthodontic plan
• Smoking or excessive alcohol consumption
• Patients with edentulous areas
• Evidence of periodontal disease (any pocket depths more than 4mm)
• Use of anti-inflammatory drugs within 2 days of bonding
• Active oral lesions (ulcerations, sores, mucositis, etc.)
• Uncontrolled diabetes
• Dentofacial deformities (cleft palate, hemifacial microsomia, etc.)
• Subjects routinely taking any of the following medications:
• Corticosteroids (including for asthma)
• Bisphosphonates
• Anti-inflammatories
• Nicotine Patch
• Estrogen
• Opioids
• Growth Hormone
• Relaxin
• Anti-coagulants
• Disease that could affect bone metabolism:
• Parathyroid or thyroid dysfunction
• Osteoporosis, osteomalacia
• Vitamin D deficiency
• Fibrous dysplasia
• Paget's Disease
• Multiple Myeloma

Where it is running

• University of Connecticut Division of Orthodontics — Farmington, Connecticut, United States

Full record on ClinicalTrials.gov

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