Atrasentan Spermatogenesis and Testicular Function

Completed · Phase 2

Conditions studied: Nephropathy, Diabetes

In brief

This study is being conducted to evaluate the effects of Atrasentan on sperm production and testicular function in male subjects with Type 1 or 2 Diabetes and Nephropathy. This study included 2 periods: a Treatment Period (up to 26 weeks) followed by an Observational Period (up to an additional 52 weeks).

Key facts

Study ID

NCT02118714

Run by

AbbVie

People needed

20

Starts

2015-04-06

Expected to finish

2018-07-16

Last updated by the study team

2019-05-07

Who can join

Age: 30 and older, up to 75. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Males 30 to 75 years of age
• Type 1 or 2 diabetes and receiving treatment with at least one anti-hyperglycemic medication and angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB) (renin-angiotensin system [RAS] inhibitor)
• Estimated Glomerular Filtration Rate (eGFR) equal to or greater than 35 mL/min/1.73 m\^2 with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Formula and Urine Albumin-to-Creatinine Ratio (UACR) equal to or greater than 30 and less than 5,000 mg/g creatinine.
• Able to provide a semen specimen at the required intervals.
• Baseline sperm concentration equal to or greater than 30 million per mL.

You may not qualify if…

• Treatment with hormone suppressive agents or cancer chemotherapy within the 6 months prior to the initial screening visit or planned during the study.
• History of severe peripheral edema or facial edema unrelated to trauma or history of myxedema in the prior 4 weeks prior to screening.
• History of pulmonary hypertension, pulmonary fibrosis or any lung disease requiring oxygen therapy.
• Documented diagnosis of heart failure, previous hospitalization for heart failure or current or constellation of symptoms (dyspnea on exertion, pedal edema, orthopnea, paroxysmal nocturnal dyspnea) felt to be compatible with heart failure, that was not explained by other causes, and for which there was a change in medication or other management directed at heart failure.
• Currently receiving or has received hormone replacement therapy within 6 months prior to screening.

Where it is running

• Alliance Research Centers /ID# 125945 — Laguna Hills, California, United States
• Frank Clark Urology Center /ID# 147794 — Santa Monica, California, United States
• Research by Design, LLC /ID# 160784 — Evergreen Park, Illinois, United States
• Southern IL Univ School of Med /ID# 129010 — Springfield, Illinois, United States
• Crescent City Clinical Res Ctr /ID# 150989 — Metairie, Louisiana, United States
• Tulane Univ /ID# 130308 — New Orleans, Louisiana, United States
• Albany Medical College /ID# 131068 — Albany, New York, United States
• Urologic Consultants of Southeastern Pennsylvania /ID# 124277 — Bala-Cynwyd, Pennsylvania, United States
• Eastern Virginia Med School /ID# 153740 — Norfolk, Virginia, United States
• Charite Research Organisation GmbH /ID# 154264 — Berlin, Germany
• Ospedale S. Carlo Borromeo /ID# 151672 — Milan, Italy
• SCDU Nefrologia e dialisi-CMID /ID# 151673 — Torino, Italy
• Hospital Universitario Reina S /ID# 151692 — Córdoba, Spain

Full record on ClinicalTrials.gov

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