Modulation of Insulin Sensitivity by Betaine Upregulation of FGF21

Completed · Not applicable

Conditions studied: Insulin Sensitivity

In brief

People with poor insulin sensitivity do not respond normally to elevations in blood sugar. This may increase their risk of developing diabetes in the future. The purpose of this research study is to determine if the nutrient betaine, found in beets, spinach and wheat products, can enhance the production of fetal growth factor 21 (FGF21), a molecule that is believed to promote insulin sensitivity.

Key facts

Study ID

NCT02118142

Run by

UNC Nutrition Research Institute

People needed

23

Starts

2014-03-01

Expected to finish

2014-07-01

Last updated by the study team

2014-08-12

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• Able/willing to consume study meals
• Non-smoker
• BMI in normal range (18-24.9)

You may not qualify if…

• Use of chronic medications
• Abnormal physical examination or chronic illness
• Use of drugs or medications known to alter choline/betaine metabolism
• Consumption of more than 2 oz of alcohol/day or 24 oz wine/day
• Use of choline/betaine-containing dietary supplements during the previous 3 months
• Diagnosed with Cystathionine Beta-Synthase (CBS) Deficiency
• Pregnant or breastfeeding
• Known hypersensitivity to betaine
• Current substance abuse or addiction

Where it is running

• UNC Nutrition Research Institute — Kannapolis, North Carolina, United States

Full record on ClinicalTrials.gov

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