Functional Image and Molecular Markers to Predict Treatment Outcomes in Lung Cancer

Stopped early

Conditions studied: Lung Neoplasms

In brief

This study is designed to apply various scans such as functional imaging, Fluorodeoxyglucose\_Positron Emission Tomography (FDG-PET), 62Cu-ETS (Copper) PET, Ventilation/Perfusion Single Photon Emission Computerized Tomography (V/Q SPECT), cardiac magnetic resonance imaging (MRI), Tc-99m HMPAO SPECT/CT, and pulmonary function tests before, during and after treatment to see if it predicts how well the treatment works for your cancer and how well your lungs function during treatment. A Computerized Tomography (CT) will also be performed along with both of these procedures to help the researchers see clearly where your cancer or your healthy lung is located. The researchers also perform blood tests in this study to look for markers in your blood to see if it helps them determine your risk of developing side effects from radiation to the lungs. They will also measure your health-related quality of life before, during and after treatment. The researchers hope that this study will help them in the future to design radiation treatment plans that provide the best treatment for each individual patient.

Key facts

Study ID

NCT02117440

Run by

Indiana University

People needed

10

Starts

2017-05-01

Expected to finish

2018-03-02

Last updated by the study team

2019-02-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed lung cancer, or clinically diagnosed lung cancer.
• AJCC stage I to IV lung cancer requiring radiation therapy (3D conformal or stereotactic) or systemic therapy, with or without surgery.
• Patients participating treatment trials including targeted therapy, experimental therapy or immunotherapy are also eligible.
• Patients with a locoregional tumor recurrence following surgery will be eligible provided they meet other eligibility criteria.
• Patients must be 18 years of age or older and able to lie flat to obtain the functional scans or have blood access for blood samples
• Female patients with reproductive capability must be willing to use effective contraception.
• Patients must be willing and able to be compliant with all procedures and visits required for this protocol (pre-treatment, during treatment, and optionally throughout follow-up period).
• Patients must sign an informed consent form for study.
• Patients must be willing and able to adhere to a special low-carb diet 24-48 hours prior to and fast 8-12 hours prior to every 18F-FDG PET scan

You may not qualify if…

• Pregnancy if the patient is receiving radiation therapy
• Lactation if the patient is receiving radiation therapy
• Patients with diabetes mellitus, with uncontrolled fasting blood glucose level (above 200 mg/dl)
• Inability to lie flat for the duration of PET/CT and V/Q SPECT/CT (approximately 45 minutes for each study)

Where it is running

• Indiana University Simon Cancer Center — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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