Endothelin Receptor Function and Acute Stress

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Hypertension

In brief

Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress. This study is an extension of the investigators previous animal work to evaluate the role of endothelin-1 during stress in humans.

Key facts

Study ID

NCT02116335

Run by

Augusta University

People needed

320

Starts

2015-06-01

Expected to finish

2026-01-01

Last updated by the study team

2025-01-28

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and premenopausal women (Ages 18-50 years old)
• Self-reported Black and White adults
• Lean adults (BMl <25 kg/m\^)
• Obese adults (BMl > 30 kg/m\^)

You may not qualify if…

• Having a BMI less than 16 kg/m2 (severely and very severely underweight) or that is greater than 40 kg/m2 (Class III obesity)
• Having evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease
• Having evidence of pregnancy
• Using medications that affect vascular tone (i.e., nitrates, etc.)
• Postmenopausal women
• Uncontrolled hypertension
• Individuals who are on a restricted salt diet
• Having a history of chronic pain
• Having a history of rheumatoid arthritis
• Using medications that are contraindicated with bosentan (i.e. glyburide, cyclosporine)
• Liver dysfunction (which may be identified with the blood sample we take)

Where it is running

• Georgia Regents University — Augusta, Georgia, United States

Full record on ClinicalTrials.gov

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