Skeletal Muscle Inflammation, Oxidative Stress and DNA Repair in Age-Related Sarcopenia

Completed

Conditions studied: Sarcopenia

In brief

The purpose of this research study is to investigate how and why the loss of muscle mass occurs with aging. Tissue collected from young subjects will be compared to previously collected tissue from elderly subjects, as well as previously collected data on muscle function/mass to further investigate cellular and molecular pathways that have recently been shown to be important for the aging process in muscle. The Principal Investigator (PI) and the study team will look for specific proteins (called biomarkers) that can be present in the muscle tissue in various amounts in different individuals. This study will increase the investigators understanding of the processes of muscle atrophy (loss of mass) and functional loss at older age and will help to find new treatments and interventions aimed at improving the quality of life and independence of America's rapidly expanding elderly population.

Key facts

Study ID

NCT02116166

Run by

University of Florida

People needed

10

Starts

2014-05-01

Expected to finish

2016-07-01

Last updated by the study team

2018-04-05

Who can join

Age: 20 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• males and females aged 20-35.
• willing and able to give informed consent.

You may not qualify if…

• High physical activity level (i.e., the subject has spent greater than 300 minutes per week in the past 2 month performing structured physical activity, such as exercising at a gym and/or weight training)
• Active treatment for cancer or history of cancer in the past 3 years
• Congestive heart failure NYHA Class III or IV
• Previous stroke with upper and/or lower extremities involvement within the last 6 months
• Peripheral vascular disease Fontaine Class III/IV
• History of life-threatening cardiac arrhythmias, stroke, severe Parkinson's disease or severe neurological disorders likely to interfere with physical function
• Renal disease requiring dialysis
• Lung disease requiring steroids
• Lower extremity amputation
• Complicated diabetes
• Life-threatening illnesses with an estimated life expectancy less than 1 year
• Anticoagulant therapy (aspirin use is allowed, but participants will be asked to stop taking it 48 hours prior to muscle biopsy)
• Involved in active weight loss > 5 kg in prior 3 months
• Pregnancy (determined by a pregnancy test)
• Lidocaine allergy
• Temporary exclusion criteria:
• Recent bacterial infection (< 2 weeks)
• Acute febrile illness in previous 2 months
• High blood pressure (i.e., BP ≥ 160/90 mm Hg) at the visit (subject will be referred to his/her physician and reevaluated after appropriated therapy being instituted)
• Taking aspirin within 48 hours preceding biopsy
• Performing exercise 48 hours prior to the biopsy.

Where it is running

• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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