The Effects of Caffeine on Pain-Based Pacing During a Cycling Time-Trial

Completed · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

Caffeine has been shown to consistently improve time-trial performance, warranting restrictions on consumption under regulation of the National Collegiate Athletics Association (NCAA) and World Anti-Doping Agency (WADA). This ergogenic effect is not well understood, possibly occurring as a result of altered metabolism, improved strength, and/or reduced muscle pain. The hypothesis of altered metabolism has recently fallen out of favor while muscular strength has a tenuous relationship with endurance exercise performance. Reductions in muscle pain have been observed during low and moderate intensity endurance exercise, and this may be the mechanism of caffeine's ergogenic effect. In lieu of reducing pain during high intensity exercise, caffeine significantly improves performance. Therefore, caffeine appears to improve the amount of work that can be done for a given muscle pain rating, suggesting that participants may pace based upon sensations of muscle pain during endurance exercise. Most time-trial exercise is conducted in a fixed distance manner, measuring the time it takes participants to cover a given distance. Little research has been conducted on a fixed pain time-trial that would require participants to produce and sustain a given level of muscle pain while measuring the distance covered in an allotted time. A fixed pain time-trial could allow researchers to better understand the effect of pain on endurance performance. The purpose of this study is to examine the effects of caffeine on a fixed pain time-trial.

Key facts

Study ID

NCT02115763

Run by

University of Oklahoma

People needed

15

Starts

2014-04-01

Expected to finish

2015-05-01

Last updated by the study team

2017-06-05

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Caffeine Naive (<40mg per day) physically active 18-35 year old men with no contraindications to exercise.

You may not qualify if…

• People who do not match the gender, age or caffeine limits;
• those with contraindications to exercise or who are not physically active

Where it is running

• University of Oklahoma Sensory and Muscle Function Lab — Norman, Oklahoma, United States

Full record on ClinicalTrials.gov

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