Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging

Completed · Phase 4

Conditions studied: Coronary Artery Disease

In brief

The purpose of this study is to measure the changes in cardiac function during a Lexiscan pharmacologic stress test using cardiac magnetic resonance imaging test.

Key facts

Study ID

NCT02115308

Run by

Timothy M. Bateman

People needed

40

Starts

2014-09-03

Expected to finish

2018-03-23

Last updated by the study team

2018-09-19

Who can join

Age: 19 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Myocardial rest/regadenoson stress perfusion PET study within 60 days
• Normal rest LVEF (greater than or equal to 50%)
• No change in symptoms or treatment between the PET and the MRI study
• Willing to consent to the study
• Male or female who is either post-menopausal, surgically sterile, or if has a childbearing potential, a negative pregnancy test within 2 days prior to the MRI study.

You may not qualify if…

• Renal dysfunction (estimated glomerular filtration rate < 60 mL/min/1.73m2) within 6 months
• Metallic implants, pacemaker, blood vessel clip (contra-indicated for MRI)
• Patient size exceeds MRI bore/table limits: (Max body diameter > 60 cm, weight > 136 kg)
• History of gadolinium contrast allergy or intolerance
• Second or third degree AV block
• Sinus node dysfunction
• Acute myocardial infarction (past 3 months)
• Actively wheezing or with acute asthma or bronchospastic attacks requiring changes in therapy within the past 30 days
• Patients that have experienced a previous hypersensitivity reaction thought to be related to regadenoson

Where it is running

• Saint Luke's Health System — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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