Pharmacokinetics of Decursin/Decursinol Angelate (CognIQTM)

Completed · Early Phase 1

Conditions studied: Healthy

In brief

This study is to investigate how human bodies absorb and metabolize two herbal drugs. The information is critical for drug development and could not be obtained from any other studies using animals. The two herbal drugs are decursin and decursinol angelate (DA) which naturally exist in a traditional herb Angelica gigas Nakai (AGN). Preclinical and clinical studies indicated that AGN and decursin/DA were quite safe to animals and human.

Key facts

Study ID

NCT02114957

Run by

Texas Tech University Health Sciences Center

People needed

20

Starts

2013-01-01

Last updated by the study team

2014-04-15

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Health subjects weighing between 50 to 91 kilograms (110 to 200 pounds)
• Subjects 18 to 65 years of age
• Subjects having normal hepatic, renal and bone marrow function as assessed by history, physical and clinical chemistry analysis

You may not qualify if…

• Subjects positive for HIV, HBV and HCV
• Subjects with diabetes-due to length of fasting
• Subjects regularly taking any kind of prescription medications
• Subjects taking oral contraception, hormone-containing IUDs, contraception implants, or Depo medroxyprogesterone injections
• Subjects taking any food or herbal supplements containing AGN (e.g. CognIQTM, D-Cursinol, Decursinol-50™, Ache Action™, Fast-Acting Joint Formula, EstroG-100™) within 30 days of the study.
• Female subjects that are pregnant, <6 months postpartum, or breastfeeding women.

Where it is running

• Clinical Research Unit, School of Medicine, Texas Tech University Health Sciences Center — Amarillo, Texas, United States

Full record on ClinicalTrials.gov

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