Very Low Density Lipoprotein Turnover in Young and Elderly Individuals

Stopped early

Conditions studied: Aging

In brief

Intrahepatic and intramyocellular lipid concentrations are elevated in elderly individuals relative to young people, despite no significant difference in fasting plasma TAG concentrations. Our general hypothesis is that the increase in intrahepatic fat with age results from reduced VLDL turnover, and therefore elderly individuals in this study will display lower VLDL turnover rates than young individuals. The aims of this study are a) to compare VLDL turnover in young and elderly individuals, and b) to compare a bolus method and a constant infusion method of assessing VLDL turnover.

Key facts

Study ID: NCT02113215
Run by: The University of Texas Medical Branch, Galveston
People needed: 24
Starts: 2011-12-01
Expected to finish: 2013-07-01
Last updated by the study team: 2016-05-12

Who can join

Age: 60 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Age 18 to 35 years, or 60 to 75 years.
Body mass index ≤ 27 kg•m2
Ability to sign informed consent.
Score of ≥26 for Mini-Mental State Exam

You may not qualify if…

Diabetics (plasma glucose concentration >200 mg/dl at 2 hr after oral intake of 75 g glucose).
Fasting plasma triacylglycerol concentration above 500 mg/dl
Kidney disease.
Liver disease.
Bleeding disorders.
Anaemia (Hb < 13 g/dl in males or < 12 g/dl in females).
Endocrine disease (with the exception of well-regulated hypothyroidism).
Positive hepatitis or HIV screens.
Alcohol (CAGE questionnaire; abnormal liver enzyme values) or drug abuse (amphetamines, cocaine, opioids, marijuana).
Lipid altering agents.
Score of <26 for Mini-Mental State Exam

Where it is running

University of Texas Medical Branch, Dept of Surgery — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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