Association of Amino Acid Prevalence and Chronic Brain Injury

Completed

Conditions studied: Chronic Traumatic Brain Injury

In brief

Years after a suffering a brain injury, individuals remain in a physically and cognitively impaired state. The investigators believe that the concentrations of amino acids in the blood are chronically altered and yield negative effects on the individuals health. Preliminary data has shown significantly lower concentrations of amino acids in serum samples from the TBI population, these diminished levels of amino acids may be due to changes in the microbiome. Understanding these changes will help guide rehabilitative services for this population. Individuals with a chronic brain injury will donate samples of blood, oral tissue, and fecal matter to be compared to that of non-injured individuals. Genetic information from the hosts will be striped and discarded; participant's genetic information will not be retained. To better understand changes in the microbiome, any history of antibiotics and probiotics will be assessed.

Key facts

Study ID

NCT02113124

Run by

Brent Masel

People needed

43

Starts

2013-12-01

Expected to finish

2014-12-01

Last updated by the study team

2015-12-15

Who can join

Age: 35 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing to donate 10 ml of blood
• Willing to donate oral tissue sample
• Willing to donate fecal sample

You may not qualify if…

• (for brain injured group) have a chronic (greater than two years) traumatic brain injury.
• Unable to provide to give voluntary informed consent

Where it is running

• Centre for Neuro Skills — Bakersfield, California, United States
• Centre for Neuro Skills — Dallas, Texas, United States
• Transitional Learning Center — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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