Exercise as an Adjunct Therapy to Reduce Blood Pressure in Chronic Kidney Disease

Completed · Not applicable

Conditions studied: Focus Chronic Kidney Disease With Hypertension

In brief

The general objective of the study is to investigate the effect of regular aerobic exercise on resting and 24-hr blood pressure levels in men and women with stage 3-4 kidney disease and hypertension.

Key facts

Study ID

NCT02112825

Run by

University of Minnesota

People needed

40

Starts

2013-07-01

Expected to finish

2015-06-01

Last updated by the study team

2017-03-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Non-diabetic and >18 years of age
• Diagnosed kidney disease with associated hypertension:
• Non-nephrotic range proteinuria at diagnosis
• No active glomerular disease or concomitant systemic inflammatory disease (e.g. lupus)
• Systolic blood pressure >130 and/or diastolic blood pressure >80 mm Hg (on medication)
• An estimated glomerular filtration rate of between 60 ml/min and 15 ml/min.
• Individuals must be able to provide informed consent
• Perform walking exercise training on a treadmill
• Be able to participate in a 12-week supervised exercise program.

You may not qualify if…

• Currently participating in a formal exercise program
• Diabetes, active glomerular disease, or systemic inflammatory disease
• Requiring dialysis
• Have an Hematocrit <27%
• Uncontrolled hypertension (>200/110mmHg)
• Peripheral vascular disease.
• An inability to understand English or give consent. Other exclusion criteria are: any contraindications to exercise testing or training as indicated by the American College of Sports Medicine guidelines such as: Unstable coronary heart disease and symptomatic heart failure, exercise capacity limited by health problems such as angina, severe arthritis, or extreme dyspnea on exertion, progressive neuromuscular disease, pulmonary disease, or having undergone a coronary revascularization within the past 6 months prior to enrollment.

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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