Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
Completed · Not applicable
Conditions studied: Congenital Heart Disease
In brief
The investigators hypothesize that intermittent bolus doses of morphine and midazolam can provide the same pain control after pediatric cardiothoracic surgery as bolus doses plus infusions while using smaller total doses of both medications. The investigators will randomize patients to receive either morphine/midazolam as needed intermittently or morphine/midazolam drips plus intermittent doses to be received as needed. Pain scores will be recorded and total medications given will be recorded.
Key facts
- Study ID
- NCT02112448
- Run by
- Wake Forest University Health Sciences
- People needed
- 78
- Starts
- 2014-06-01
- Expected to finish
- 2016-05-01
- Last updated by the study team
- 2024-10-24
Who can join
Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 3 months - 4 years (48 months)
- Anticipated cardiothoracic surgery with midline sternotomy incision
- Planned early extubation (e.g. within 3 hours post surgery)
You may not qualify if…
- Presence of renal insufficiency defined as a creatinine greater than 0.8mg/dL on the standard basic metabolic profile sent after surgery or history of chronic renal failure.
- Significant development delay that the bedside nurse or treating physician judges would make pain scoring difficult (Down syndrome is not excluded)
- History of bleeding disorder or gastrointestinal bleed within the past 2 months.
- Presence of chronic hepatic disease or elevation of AST or ALT greater than 250 U/L before or after surgery.
- More than 3 previous surgeries with a sternotomy incision (this may alter pain perception).
- Children on immunosuppressants
Where it is running
- Advocate Children's Hospital — Oak Lawn, Illinois, United States
Full record on ClinicalTrials.gov
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