Icariin to Prevent Corticosteroid-related Memory Changes

Completed · Phase 1 · Has a placebo group

Conditions studied: the Pharmacokinetic Profile of Icariin in Humans

In brief

The purpose of this study is to investigate the pharmacokinetic properties of icariin, an active ingredient in the over-the-counter supplement, Horny Goat Weed.

Key facts

Study ID

NCT02112123

Run by

University of Texas Southwestern Medical Center

People needed

24

Starts

2014-04-01

Expected to finish

2016-12-01

Last updated by the study team

2017-08-18

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women
• Ages 18 - 50 years
• BMI between 18.5 and 30
• Ability to read and speak English
• Education of 12 or more years or equivalent (at least GED received)

You may not qualify if…

• Medication changes in the past 30 days
• History of psychotropic medication therapy in the past 30 days
• Current or past 30 days opioid therapy
• Current or past 30 days erectile dysfunction therapy
• Significant medical conditions
• Hypertensive blood pressure, defined as either systolic pressure > 140 or diastolic pressure > 90
• Baseline heart rate > 100 bpm or < 50 bpm
• History of major psychiatric illness
• History of drug/alcohol abuse or current tobacco use
• Vulnerable populations including pregnant or nursing women, the incarcerated, or individuals with severe cognitive disorders
• History of allergic reaction or contraindication to icariin
• Baseline QIDS score > 7, current suicidal ideation, or history of suicide attempt
• Education history that includes Special Education or history of mental disability
• Clinically significant abnormalities on baseline labs and ECG results
• Current participation in any other pharmacotherapy studies

Where it is running

• UT Southwestern Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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