Observational Study of Keratoconus and Post-keratoplasty Eyes
Completed
Conditions studied: Keratoconus and Post-keratoplasty
In brief
A prospective observational study on keratoconus and post-keratoplasty will be conducted. We will enroll 50 subjects in each of 3 groups: keratoconus, post-PK, and post-DSAEK. The Optovue anterior segment OCT prototype will be used to perform 3-D corneal scans. These scans will be used to measure corneal thickness (pachymetry), corneal topography (anterior and posterior) and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-ring corneal topography, ultrasound pachymetry, and Scheimpflug camera imagery, will be performed for comparison. In some post-PK and post-DSAEK cases, vision will be primarily affected by regular astigmatism, myopia, or hyperopia, rather than HOA. These cases can be corrected by standard PRK (not OCT guided) with adjunctive mitomycin C treatment to prevent haze formation.107, 108 In these cases PRK will be performed according to the standard of care and will not be a part of the study protocol. The postoperative results will be observed at the 3-4 month visit with UCVA, manifest refraction, BSCVA, OCT scanning, Placido topography, ultrasound pachymetry, and Scheimpflug camera imagery
Key facts
- Study ID
- NCT02109848
- Run by
- Oregon Health and Science University
- People needed
- 7
- Starts
- 2011-06-01
- Expected to finish
- 2017-08-31
- Last updated by the study team
- 2018-04-06
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults (18 \& older) with keratoconus, keratoplasty, DSAEK procedures
You may not qualify if…
- Inability to give informed consent.
- Inability to maintain stable fixation for OCT imaging.
- Inability to commit to required visits to complete the study.
Where it is running
- Casey Eye Institute, Oregon Health & Science University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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