[18F] Flourothymidine (FLT) PET/CT Imaging for Gynecologic Cancers

Completed

Conditions studied: Gynecologic Cancer

In brief

The purpose of this study is to determine the effect of specific bone marrow maps developed with18F-FLT PET/CT imaging on the ability to spare proliferating bone marrow using proton beam radiotherapy compared to IMRT. Participants will be 18 years of age or old with a history of gynecologic cancer. Subjects will undergo 3 FLT-PET scans (one before treatment, one during the course of RT, and one 2-5 weeks after initiation of RT). Scans will take place in the Department of Radiation Oncology.

Key facts

Study ID

NCT02108457

Run by

Abramson Cancer Center at Penn Medicine

People needed

15

Starts

2014-02-01

Expected to finish

2016-12-21

Last updated by the study team

2021-03-30

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Participants will be 18 years of age or older
• History of gynecologic cancer.
• Recommended to undergo IMRT or PBT of the pelvis with concurrent chemotherapy
• Female participants of child-bearing potential must have a negative urine or serum pregnancy test at the time of the screening visit.
• Participants must be informed of the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study specific procedures.
• Participants must be willing and able to comply with scheduled visits and imaging procedures in the opinion of the investigator or treating physician.

You may not qualify if…

• Females who are pregnant or breast feeding at the time of screening will not be eligible for this study.
• Inability to tolerate imaging procedures in the opinion of the investigator or treating physician
• Serious or unstable medical or psychological conditions that, in the opinion of the investigator would compromise the subjects safety or successful participation in the study.
• Unwilling or unable to provide informed consent

Where it is running

• Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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