Skeletal Muscle Perfusion With LVAD

Status unconfirmed

Conditions studied: Heart Failure

In brief

Advanced heart failure (when the heart pump fails) is associated with symptoms such as shortness of breath and extreme fatigue. Some of these symptoms are simply due to failure of the pump, however abnormal regulation of blood flow to the muscles of the body is also a potential mechanism. Left ventricular assist devices are mechanical pumps used to compensate for patients with failing hearts either as a bridge to heart transplant or as long term therapy. Whether or not these pumps improve muscle flow and whether this is a determinant in the improvement of symptoms is unknown. Understanding how skeletal muscle and heart perfusion is altered in heart failure patients before and after implantation of an LVAD could provide further insight into the beneficial effects of this therapy. Specific Aims: 1. To evaluate skeletal muscle and heart perfusion studies before and after LVAD implantation 2. To compare functional status with degree of skeletal muscle perfusion.

Key facts

Study ID

NCT02105831

Run by

Oregon Health and Science University

People needed

30

Starts

2014-02-01

Expected to finish

2019-12-01

Last updated by the study team

2018-08-23

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients deemed to be candidates for a LVAD

You may not qualify if…

• severe peripheral artery disease
• skeletal muscle disorder
• severe congenital heart disease
• pregnancy
• patients <18 yo

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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