Optimizing Cognitive Remediation Outcomes in Schizophrenia

Completed · Not applicable

Conditions studied: Schizophrenia, Psychosis

In brief

The purpose of this study is to drive an optimal response to neuroplasticity-based cognitive remediation in schizophrenia in order to maximize treatment response. The investigators will investigate factors that have generally been ignored in prior computer-based cognitive remediation programs-those related to social cognition-- and will delineate their relationship to motivation, functional outcome, and the neural substrates of reward anticipation and emotion processing. Current research indicates that, unless the investigators fully understand and harness these factors, the investigators will not achieve meaningful treatment gains for individuals with schizophrenia.

Key facts

Study ID

NCT02105779

Run by

University of California, San Francisco

People needed

172

Starts

2009-12-01

Expected to finish

2016-07-26

Last updated by the study team

2019-04-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Clinical diagnosis of schizophrenia or schizoaffective disorder
• Between 18-65 years of age
• Clinically stable
• Fluent in English

You may not qualify if…

• Recent hospitalization, in the past 3 months
• History of traumatic brain injury
• Neurological disorders
• Inability to participate in the study soberly

Where it is running

• San Francisco Veterans Medical Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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