Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

Completed · Phase 2/Phase 3

Conditions studied: Critical Illness

In brief

The hypothesis of this study is that a Ketamine / Propofol mixture will produce more stable hemodynamics as compared to Etomidate during emergent intubations in the intensive care unit. Patients that require a breathing tube to be placed in the ICU will be randomized to receIve either a Ketamine / Propofol mixture or Etomidate for sedation in order to place the breathing tube.

Key facts

Study ID

NCT02105415

Run by

Mayo Clinic

People needed

160

Starts

2014-04-01

Expected to finish

2018-08-01

Last updated by the study team

2020-06-16

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Surgical or medical intensive care unity patients requiring endotracheal intubation
• Consulting physician agrees to study plan and will follow drug randomization

You may not qualify if…

• Known intracranial pathology
• Known chronic opiate-dependence
• Received continuous sedative infusion in the last 24 hours
• Known severe psychiatric illness
• Known egg allergies
• Known contraindication to fentanyl, midazolam, ketamine, propofol or etomidate
• Intubation in which standard practice is not to use sedation
• No known documented weight or weight greater than 140 kg or less than 30 kg
• Prior participation in the study
• Of childbearing age (18-50) with no known negative pregnancy test on this admission.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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