Chest Wall Influence on Respiratory System Mechanics in Morbidly Obese Patients
Completed
Conditions studied: Obesity, Intra-Abdominal Hypertension
In brief
The goal of this study is to describe the influence of the chest wall on the respiratory system mechanics in morbidly obese patients and in patients with high intra-abdominal pressure. The effects of increasing and decreasing positive end-expiratory pressure (PEEP) on chest wall and total respiratory system mechanics, lung volumes and gas exchange will be evaluated, both during controlled and assisted mechanical ventilation. Patients will be studied, first, during the acute phase of respiratory failure, when requiring intubation and controlled mechanical ventilation. Then, patients will be evaluated again during weaning from the ventilator to assess the influence of PEEP in assisted ventilation prior to extubation.
Key facts
- Study ID
- NCT02105220
- Run by
- Massachusetts General Hospital
- People needed
- 14
- Starts
- 2013-08-01
- Expected to finish
- 2015-03-01
- Last updated by the study team
- 2015-03-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years or older
- Requiring intubation and mechanical ventilation
- BMI≥40 kg/m2 or IAP≥12 mmHg
You may not qualify if…
- Known presence esophageal varices
- Recent esophageal trauma or surgery
- Severe thrombocytopenia (PTL≤10,000/mm3)
- Severe coagulopathy (INR≥2)
- Presence of pneumothorax
- Pregnancy
- Patients with diagnosed moderate to severe ARDS or with poor oxygenation index (PaO2/FiO2 < 200 mmHg)
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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