Assisting Obsessive Compulsive Disorder (OCD) Patients With Discontinuing Long-term Serotonin Reuptake Inhibitors (SRIs)
Completed · Not applicable
Conditions studied: Obsessive Compulsive Disorder
In brief
This study will address questions of fundamental clinical significance including: (1) whether OCD patients maintained on long term SRIs can be discontinued without symptom exacerbation, (2) whether trans-diagnostic cognitive-behavioral treatment will reduce worsening following discontinuation compared to Taper and Monitoring, and (3) whether predictors of successful SRI discontinuation can be identified.
Key facts
- Study ID
- NCT02103621
- Run by
- Butler Hospital
- People needed
- 14
- Starts
- 2014-05-01
- Expected to finish
- 2018-01-01
- Last updated by the study team
- 2018-06-14
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 or older
- Presence of mild to moderate OCD symptoms
- Patient's treating clinician agrees that SRI discontinuation is clinically appropriate
- Adequate trial of SRI (≥10 weeks) in the current treatment episode
- Maintenance on SRI dose that has not increased due to significant clinical worsening in the two years prior to enrollment
- English speaking
You may not qualify if…
- Clinically significant suicidality or a suicide attempt within the past year
- Presence of any clinical features warranting a higher level of care (partial or inpatient hospitalization)
- Current or recent (past 6 months) alcohol or drug dependence or abuse
- Current or past psychotic disorder or bipolar disorder
- Moderate to severe depression, as indicated by a Hamilton Rating Scale for Depression (HRSD) (17-item) ≥ 14 or recent major depressive episode (past 6 months)
- History of severe OCD (YBOCS ≥ 28)
- Prior adverse experience with SRI discontinuation
- Primary compulsive hoarding
- Cognitive impairment that would interfere with study participation
- Concomitant psychosocial treatment w/ proven efficacy in the treatment of OCD
- Previous adequate trial of exposure-based treatment (e.g., history of 12 or more sessions) in past 5 years
- Use of non-SRI psychotropic medications for OCD in the 3 months prior to enrollment.
Where it is running
- Butler Hospital — Providence, Rhode Island, United States
Full record on ClinicalTrials.gov
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