The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
Completed · Not applicable
Conditions studied: Nicotine Dependence
In brief
This study will help determine if menthol administered by inhalation via electronic cigarettes (e-cigarette) changes the reinforcing effects of pure nicotine administered intravenously in cigarette smokers who smoke mentholated or non-mentholated cigarettes.
Key facts
- Study ID
- NCT02102100
- Run by
- Yale University
- People needed
- 57
- Starts
- 2014-03-26
- Expected to finish
- 2016-07-11
- Last updated by the study team
- 2020-03-19
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Female and male smokers, aged 18 to 30 years;
- History of smoking for the past 12 months, at least one cigarette per day; smoking status is verified with urinary cotinine levels above 10 ng/ml;
- Not seeking treatment for nicotine dependence at the time of study entry;
- In good health as verified by medical history, screening examination, and screening laboratory tests;
- For women, not pregnant as determined by pregnancy screening, nor breast feeding, and using acceptable birth control methods.
You may not qualify if…
- History of major medical illnesses that the physician investigator deems as contraindicated for the patient to be in the study
- Regular use of psychotropic medication (antidepressants, antipsychotics, or anxiolytics);
- A psychiatric diagnosis and / or treatment for Axis I disorders including major depression, bipolar affective disorder, schizophrenia or panic disorder in the past month
- Abuse of alcohol or any other recreational or prescription drugs in the past 30 days.
- Any allergy to propylene glycol or menthol.
Where it is running
- Connecticut VA Healthcare System — West Haven, Connecticut, United States
- VA Connecticut Health Care System — West Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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