Pilot Study to Test Dietary Fat Delivery
Completed
Conditions studied: Insulin Resistance
In brief
The average American diet consumed by a significant proportion of the adult population, supplies excessive calories and large amounts of saturated fat. Saturated fats can be cleared and used in skeletal muscle, but in obese individuals, biomarkers of saturated fat are found in the blood, along with markers of poor muscle metabolism. Both fats and amino acids are processed by the same metabolic pathways in muscle, and the investigators hypothesize that meals with greater amounts of saturated fat slow muscle metabolism. A better understanding of the interaction of these to metabolites will allow for the development of future medications to treat muscle loss in sick individuals and the elderly.
Key facts
- Study ID
- NCT02101996
- Run by
- University of Missouri-Columbia
- People needed
- 9
- Starts
- 2014-06-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2016-08-19
Who can join
Age: 30 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Lean/insulin sensitive (n=10, BMI ≤ 24 kg/m2 and glucose infusion > 4.0 mg/min))
- Overweight/obese insulin resistant (n=10, BMI 26-35 and glucose infusion < 4.0 mg/min)
- 30-50 years of age
- Men and pre-menopausal women
You may not qualify if…
- Insulin resistance is defined by insulin clamp as the rate of glucose infusion ≤ 4.0 mg/min.
- BMI over 35 kg/m2
- Abnormal thyroid function, kidney or liver disease
- Uncontrolled hypertension, or occasional or regular smoker, use of medications or supplements that interfere with lipid, protein, or carbohydrate metabolism
- Pregnancy (urine test), breast feeding an infant, or anemia
- Alcohol intake: Males >140 g/week, Females > 70 g/week.
- Fasting plasma triglycerides >300 mg/dL. Extreme hypertriglyceridemia could be due to either elevations in very low-density lipoproteins or chylomicrons, either of which would impair our ability to resolve dietary metabolic processes.
- Need to consume acetaminophen-containing medications on a regular basis.
Where it is running
- University of Missouri — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
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