Strength Training and Endurance Exercise for LIFE

Completed · Not applicable

Conditions studied: HIV

In brief

Research is needed to determine safe and effective exercise rehabilitation programs to prevent and improve physical disability in older adults living with HIV. This problem is of great importance to the VA. The majority of the 25 thousand HIV-infected veterans are over 50 years of age (64%). The combined effect of aging and inflammation increase the risk for physical disability in older HIV-infected veterans. This translational exercise training trial will examine the cardiac and skeletal muscle effects of combined aerobic exercise and resistance training to attenuate the functional declines of aging with HIV by reducing the deleterious consequences of chronic inflammation. Findings will guide future rehabilitation research on cardiac remodeling and inflammation of skeletal muscle. The proposed research will advance the goal to develop effective rehabilitation strategies that improve the health of older HIV-infected veterans.

Key facts

Study ID

NCT02101060

Run by

VA Office of Research and Development

People needed

33

Starts

2014-09-15

Expected to finish

2019-10-04

Last updated by the study team

2026-04-22

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV-infected veterans adult 50 years of age and older under medical care for HIV
• Antiretroviral Therapy

You may not qualify if…

• Patients with comorbid conditions that could have a potential impact on their ability to perform exercise testing and training will be excluded according to the American College of Sports Medicine
• Only sedentary adults will be eligible. Individuals that participate in regular structured aerobic exercise or resistance training in the prior 6-months will be excluded

Where it is running

• Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD — Baltimore, Maryland, United States
• Salem VA Medical Center, Salem, VA — Salem, Virginia, United States

Full record on ClinicalTrials.gov

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