Restoration of Retinal Vascular Responses in Type 1 Diabetic Patients
Completed · Phase 1
Conditions studied: Diabetic Retinopathy
In brief
Diabetic retinopathy is the leading cause of blindness in the developed world. The causes of the disease are poorly understood. One of the earliest changes that occur in the retinas of diabetic patients, well before overt retinopathy is observed, is a reduction in light-evoked increases in blood flow in retinal vessels. The loss of this vascular response may lead to retinal hypoxia and it has been suggested that hypoxia could be a principal cause of diabetic retinopathy. The long-term goals of this project are to determine whether decreased blood flow in diabetic patients and the resulting retinal hypoxia contributes to the development of diabetic retinopathy and whether restoration of normal blood flow in diabetic patients slows or prevents the development of retinopathy.
Key facts
- Study ID
- NCT02099981
- Run by
- University of Minnesota
- People needed
- 34
- Starts
- 2016-07-01
- Expected to finish
- 2017-12-01
- Last updated by the study team
- 2018-01-18
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Type 1 diabetes between 18 and 65 years of age
- Diabetes duration between 5 to 20 years.
- Normal report or minor findings on a dilated eye exam
- Healthy subjects on no medications
You may not qualify if…
- Current diagnosis or history of:
- hypertension
- dyslipidemia
- epilepsy
- glaucoma or other ocular disease
- renal insufficiency/failure (creatinine >1.5 mg/dL)
- pregnancy or breastfeeding.
- smoker
Where it is running
- University of Minnesota Medical Center Fairview — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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