Dose Ranging Study of RPC4046 in Eosinophilic Esophagitis

Completed · Phase 2 · Has a placebo group

Conditions studied: Eosinophilic Esophagitis

In brief

The purpose of this study is to determine the effective dose(s) of RPC4046 in the treatment of Eosinophilic Esophagitis (EoE). This trial consists of two phases: 16 weeks of double-blind treatment and 52 weeks of open-label extension.

Key facts

Study ID

NCT02098473

Run by

Celgene

People needed

100

Starts

2014-08-31

Expected to finish

2017-01-30

Last updated by the study team

2017-05-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologic evidence of EoE
• Clinical symptoms of EoE including dysphagia

You may not qualify if…

• Primary causes of esophageal eosinophilia other than EoE

Where it is running

• Mayo Clinic - Arizona — Scottsdale, Arizona, United States
• Desert Sun Clinical Research, LLC — Tucson, Arizona, United States
• Alliance Clinical Research — Oceanside, California, United States
• Precision Research Institute, LLC — San Diego, California, United States
• University of Colorado School of Medicine — Aurora, Colorado, United States
• Connecticut Clinical Research Foundation — Bristol, Connecticut, United States
• University of Florida — Gainesville, Florida, United States
• Borland-Groover Clinic — Jacksonville, Florida, United States
• Children's Center for Digestive Healthcare — Atlanta, Georgia, United States
• Grand Teton Research Group — Idaho Falls, Idaho, United States
• Northwestern University-Feinberg School of Medicine — Chicago, Illinois, United States
• Southwest Gastroenterology — Oak Lawn, Illinois, United States
• Indiana University — Indianapolis, Indiana, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Gastroenterology and Hepatology Service Walter Reed National Military Medical Center — Bethesda, Maryland, United States
• Metropolitan Gastroenterology Group Chevy Chase Clinical Research — Chevy Chase, Maryland, United States
• West Michigan Clinical Research Center Gastroenterology Associates of Western Michigan — Wyoming, Michigan, United States
• Minnesota Gastroenterology — Plymouth, Minnesota, United States
• GI Associates and Endoscopy Center-GI Clinical Research Department — Flowood, Mississippi, United States
• Darthmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States
• Asheville Gastroenterology Associates, PA — Asheville, North Carolina, United States
• University of North Carolina — Chapel Hill, North Carolina, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Great Lakes Gastroenterology Research — Mentor, Ohio, United States
• University of Pennsylvania Perelman Center for Advanced Medicine — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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