Study Of Three Different Stomach Acid Reducing Agents When Given With Palbociclib (PD-0332991) And Food

Completed · Phase 1

Conditions studied: Healthy

In brief

To investigate the effect of acid reducing agents (an antacid and an H2-receptor antagonist and a proton pump inhibitor) on palbociclib bioavailability in the presence of food.

Key facts

Study ID

NCT02097329

Run by

Pfizer

People needed

27

Starts

2014-04-01

Expected to finish

2014-06-01

Last updated by the study team

2014-06-19

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male and/or female subjects of non-childbearing potential between the ages of 18 and 55 years, inclusive.
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs).
• Willing and able to comply with all scheduled visits, treatment plan, laboratory tests, and other study procedures.

You may not qualify if…

• Evidence or history of clinically significant diseases (hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease).
• Use of tobacco or nicotine containing products within 3 months of screening.
• A positive urine drug screen.

Where it is running

• Pfizer Investigational Site — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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