Correlation Between Trachebroncho Malacia/Hyperdynamic Airway Collapse And Obstructive Sleep Apnea
Completed
Conditions studied: Trachebronchomalacia (TBM), Hyper Dynamic Airway Collapse (HDAC), Obstructive Sleep Apnea (OSA)
In brief
The investigators hypothesize that there is a strong correlation between OSA and TBM/HDAC. Our hypothesis is based on the similarities in mechanism (airway collapse), symptoms (daytime and nocturnal dyspnea) predisposing conditions (obesity and neuromuscular abnormalities of the chest wall and the diaphragm), and effect of interventions (CPAP and BIPAP) in these diseases.
Key facts
- Study ID
- NCT02097212
- Run by
- National Jewish Health
- People needed
- 1
- Starts
- 2014-03-01
- Expected to finish
- 2015-03-01
- Last updated by the study team
- 2017-03-29
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Females and males ages 18-80 years old
- Able and willing to provide written informed consent
- Existing diagnosis of TBM or HDAC or both
- No pre-existing diagnosis of OSA
- No history of reconstructive surgery of chest wall or diaphragm
You may not qualify if…
- Inability to provide informed consent
- Non-English speaking
- Poorly controlled congestive heart failure
- Untreated Insomnia
- Severe Coronary artery disease with active symptoms of angina
- Patient is pregnant, or plans to become pregnant in next 3 months
- Moderate to severe bronchiectasis
- Severe untreated gastroesophageal disease (GERD).
- Moderate to large hiatal hernia deemed to be atleast in part responsible for TBM/HDAC
- Airway obstruction not caused by TBM /HDAC or secondary TBM/HDAC caused by conditions such as Chronic Obstructive Pulmonary Disease (COPD).
- Active or recent (with in last one year) cancer or cancer therapy (chemotherapy, radiation therapy or surgery)
- Inability to properly perform the home sleep test
- Unreliable test data after 2 attempts
- BMI>45
Where it is running
- National Jewish Health — Denver, Colorado, United States
Full record on ClinicalTrials.gov
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