Pharmacogenomic Testing Of the Elderly To Reduce Morbidity

Status unconfirmed

Conditions studied: Genetics of Drug Metabolism

In brief

The goal of the POETRY Registry is to determine whether data from Pharmacogenomic (PGx) Testing for elderly and disabled patients can help physicians manage patient medication regimens and assess if the testing has an effect on reducing adverse drug events, hospitalizations, and emergency department visits. The way an individual processes or metabolizes a drug is in part determined by their genes, and there is known to be genetic variation from one human to another. The study of the way in which genes affect an individual's response to drugs is known as "Pharmacogenomics."

Key facts

Study ID

NCT02095769

Run by

General Genetics Corporation

People needed

280000

Starts

2014-04-01

Expected to finish

2017-01-01

Last updated by the study team

2015-02-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject underwent PGx testing for the alleles appropriate to the target drugs within the prior 90 days ('index PGx test')
• Males and females aged ≥65 years or male and females aged ≥18 years who have a disability
• Subject is able and willing to provide written informed consent
• Subject was receiving at least one medication known to be associated with allelic variation at the time of the index PGx test, including over-the-counter medications
• Subject has a history of at least one target drug-related adverse event (TDAE) over the 12-month period preceding receipt of PGx test results, or has experienced inadequate efficacy from a target drug

You may not qualify if…

• Subject is currently hospitalized
• Subject's medical and medication history is unavailable over the 90-day period preceding the receipt of PGx test results
• Subject is unable to provide an accurate history due to mental incapacity
• Subject is known to have undergone prior PGx testing for genes specific to the target drug(s), exclusive of the PGx test relating to this Registry

Where it is running

• Core Insitute — Phoenix, Arizona, United States (enrolling)
• LifeSpan Institute — La Jolla, California, United States (enrolling)
• The International Heart & Lung Institute Center for Restorative Medicine — Palm Springs, California, United States (enrolling)
• Research Physicians Network Alliance — Pembroke Pines, Florida, United States (enrolling)
• Tallahassee Neurological Institute — Tallahassee, Florida, United States (enrolling)
• Hypertension Institute — Nashville, Tennessee, United States (enrolling)
• Diagnostic Clinic of Houston — Houston, Texas, United States (enrolling)
• Research & Cardiovascular Corp. — Ponce, PR, Puerto Rico (enrolling)

Full record on ClinicalTrials.gov

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