Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications

Completed · Phase 1/Phase 2

Conditions studied: Blood Transfusion Complications

In brief

This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac surgical population.

Key facts

Study ID

NCT02094118

Run by

Mayo Clinic

People needed

171

Starts

2016-01-01

Expected to finish

2019-05-30

Last updated by the study team

2021-04-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age equal to or greater than 18 years of age.
• Scheduled to have cardiac bypass surgery at Mayo Clinic in Rochester, Minnesota or Duke University Medical Center in Durham, North Carolina
• At risk for needing at least 4 units of blood during/after surgery

You may not qualify if…

• Emergency surgery
• Immunoglobulin A (IgA) deficiency
• History of severe recurrent transfusion reactions
• Refusal to receive allogeneic blood products
• Refusal to provide informed consent
• Prevalent lung injury prior to randomization
• Prevalent congestive heart failure prior to randomization
• Expected hospital stay < 48 hours
• Not anticipated to survive > 48 hours
• Previously enrolled in this trial
• No plan for placement of a pulmonary artery catheter
• Use of home oxygen therapy
• Complex RBC antibody profiles
• Need for the use of irradiated RBCs

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States
• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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