Effect of Skipping Breakfast on Metabolic Function

Completed · Not applicable

Conditions studied: Skipping Breakfast, Circadian Rhythms

In brief

The purpose of this study is to test the hypothesis that the disruption of the "normal" (three meals a day) eating pattern and prolonged overnight fasting caused by skipping breakfast: i) alters the expression of specific clock genes and clock gene targets involved in regulating adipose tissue lipolysis (breakdown or destruction); ii) increases basal adipose tissue lipolytic (breakdown) activity and plasma free fatty acid (FFA) concentrations; iii) reduces skeletal muscle insulin sensitivity; and iv) increases daylong plasma glucose, FFA, and insulin concentrations. The investigator will do this by studying healthy, lean persons either randomized to consume either 3 standard meals per day or omit breakfast and consume 2 meals per day without changing daily calorie intake (skipping breakfast group).

Key facts

Study ID

NCT02093572

Run by

Washington University School of Medicine

People needed

30

Starts

2014-05-01

Expected to finish

2017-05-05

Last updated by the study team

2021-03-26

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males \& females
• 18-55 years old
• BMI between 18.5 - 29.9 kg/m²
• Sleeps >7 hours/night
• Normally consume 3 meals/day, including breakfast

You may not qualify if…

• Pregnancy, lactating or breastfeeding
• Diabetes
• Sleep disorders
• Significant organ dysfunction
• Shift or nighttime workers
• Smokers
• Breakfast skippers
• People who regularly sleep <7 hours/night
• Consume excess amounts of alcohol
• Medications that could alter the results of this study

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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