African American Alzheimer's Progression Markers - CSF and Neuro-Imaging

Completed

Conditions studied: Mild Cognitive Impairment, Alzheimer's Disease

In brief

African Americans are twice as likely to develop Alzheimer's disease as white Americans, but few African Americans are enrolled in large Alzheimer's biomarker studies. The current proposal aims to determine the influence of Alzheimer's disease and vascular disease on memory and aging in African Americans through modern biomarkers (spinal fluid, MRI, and amyloid imaging), and how these may differ between African Americans and white Americans in preparation for a large multi-center study of aging in African American.

Key facts

Study ID

NCT02089555

Run by

Emory University

People needed

135

Starts

2013-09-01

Expected to finish

2016-06-01

Last updated by the study team

2016-06-23

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 60-85.
• Has normal cognition, a diagnosis of mild cognitive impairment, or a diagnosis of Alzheimer's disease or mild cognitive impairment.
• Self-reported race of African American or non-Hispanic white.
• Able to undergo neuropsychological testing, lumbar puncture, and MRI.
• English speaking.

You may not qualify if…

• History of stroke.
• Diagnosis of Parkinson's disease, amyotrophic lateral sclerosis, or another progressive neurological disorder which may spare cognition.
• Mini-Mental State Examination (MMSE) < 17

Where it is running

• Emory University — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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