Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Completed · Not applicable

Conditions studied: Carotid Stenosis

In brief

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.

Key facts

Study ID

NCT02089217

Run by

Mayo Clinic

People needed

2486

Starts

2014-12-09

Expected to finish

2025-09-12

Last updated by the study team

2025-10-01

Who can join

Age: 35 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Huntsville Hospital/ Heart Center Research Alabama — Huntsville, Alabama, United States
• Banner University Medical Center — Phoenix, Arizona, United States
• St. Joseph's Hospital and Medical Center/Barrow Neurological Institute — Phoenix, Arizona, United States
• Abrazo Arizona Heart Hospital — Phoenix, Arizona, United States
• Mayo Clinic Arizona — Phoenix, Arizona, United States
• HonorHealth Scottsdale Osborn Medical Center — Scottsdale, Arizona, United States
• Banner University Medical Center — Tucson, Arizona, United States
• Central Arkansas Veteran's Healthcare System — Little Rock, Arkansas, United States
• Mission Cardiovascular Research Institute — Fremont, California, United States
• Mission Cardiovascular Research — Fremont, California, United States
• University of California Irvine — Irvine, California, United States
• UC San Diego Health — La Jolla, California, United States
• Kaiser Permanente Los Angeles — Los Angeles, California, United States
• Keck Medical Center of University of Southern California — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• University of California Los Angeles (UCLA) — Los Angeles, California, United States
• VA Palo Alto Health Care System — Palo Alto, California, United States
• University of California San Diego — San Diego, California, United States
• Kaiser Permanente — San Diego, California, United States
• Kaiser Permanente Northern California — San Francisco, California, United States
• University of California San Francisco — San Francisco, California, United States
• San Francisco VA Medical Center — San Francisco, California, United States
• Stanford University Medical Center — Stanford, California, United States
• St. Joseph's Medical Center — Stockton, California, United States
• The University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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