Amniotic Membrane in Total Knee Replacements to Reduce Scarring

Completed · Not applicable

Conditions studied: Scarring

In brief

The overall objective of this study is to evaluate the effectiveness of dHACM in reducing scar tissue formation in total knee replacement patients.

Key facts

Study ID

NCT02088567

Run by

MiMedx Group, Inc.

People needed

52

Starts

2014-01-01

Expected to finish

2014-10-01

Last updated by the study team

2015-09-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Are adults ages 18 or older.
• Are diagnosed with advanced osteoarthritis as determined by clinical exam and necessitate total knee replacement.
• Have a willingness to comply with follow-up examination.
• Have ability to give full written consent.

You may not qualify if…

• Has had a previous total or partial joint replacement performed at the same site
• Has a planned bilateral procedure at this time. Bilateral patients can be enrolled if the procedures are staged.
• Has signs or symptoms of any other disease which could result in allograft failure, or has experienced allograft failure in the past.
• Has used any investigational drug(s) or therapeutic device(s) within 30 days preceding screening.
• Is pregnant or may become pregnant during the study.
• Is a prisoner.
• Has any condition(s) which seriously compromises the subject's ability to participate in this study, or has a known history of poor adherence with medical treatment.
• Is currently taking medications which could affect allograft incorporation (supervising physician's discretion).
• Is confined to bed or a wheelchair.
• Has clinical signs and symptoms of local infection at the site.
• Has autoimmune disease or a known history of having Acquired Immunodeficiency Syndrome (AIDS) or HIV.
• Has current diagnosis of cancer at the site.
• Has had prior radiation therapy treatment at the site.
• Is currently taking anticoagulant therapy.
• Is unable to sign or understand informed consent.
• Has a history of drug or alcohol abuse within last 12 months.
• Is allergic to Aminoglycoside antibiotics (such as gentamicin and/or streptomycin).

Where it is running

• Georgia Knee and Sports Medicine — Decatur, Georgia, United States

Full record on ClinicalTrials.gov

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