Measurement of Pulmonary Transit Time by Echocardiography: Comparison With Cardiac MRI
Completed
Conditions studied: Patients Undergoing Cardiac Surgery
In brief
The focus of the present study is to further develop an echocardiographic technique to measure cardiopulmonary transit time (PTT) and pulmonary blood volume (PBV) using ultrasound contrast. The Specific Aims for the present study are as follows: 1. To compare echocardiography-based PTTs and cardiac MRI-based PTTs obtained using a 'peak-to-peak' method 2. To further quantify the relationship between echocardiographically-derived PTT, using Optison, and existing echocardiographic methods used to determine ventricular function 3. To measure the reproducibility of echocardiographically-based PTT using Optison.
Key facts
- Study ID
- NCT02088320
- Run by
- Vanderbilt University
- People needed
- 17
- Starts
- 2013-11-01
- Expected to finish
- 2018-10-01
- Last updated by the study team
- 2019-02-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female sex, age >18 years who are having an echocardiogram done for clinical reasons. Based on the potential for further support of our work, this may expand to include volunteers who would otherwise not be undergoing an echocardiogram.
- Negative pregnancy test for women of childbearing potential
- If eligible for cMRI, estimated glomerular filtration rate (eGFR) of > 30 mL/min
- If eligible for cMRI, cMRI checklist obtained
- Able to give informed consent
You may not qualify if…
- Unable to give informed consent
- Known right-to-left, bidirectional, or transient right-to-left cardiac shunts
- Currently participating in another clinical treatment trial
- Known allergic reaction to Optison ultrasound contrast
- If eligible for cMRI, known allergic reaction to cMRI contrast
- If eligible for cMRI, contraindication to cMRI
- If eligible for cMRI, pre-cMRI eGFR < 30 mL/min
- Pregnancy/Nursing
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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