Duration of Red Blood Cell Storage Prior to Transfusion

Completed · Not applicable

Conditions studied: Iron, Blood Level Abnormal

In brief

This study will determine the minimal duration of red blood cell (RBC) storage that leads to increases in circulating non-transferrin-bound iron in healthy human volunteers post-transfusion. The results from this study will help guide national guidelines for appropriate duration of RBC storage prior to transfusion, which is currently 6 weeks by Food and Drug Administration (FDA) criteria. The overall objective of this research is to improve the safety of refrigerated storage of red blood cells before transfusion.

Key facts

Study ID

NCT02087514

Run by

Columbia University

People needed

60

Starts

2014-02-01

Expected to finish

2016-02-01

Last updated by the study team

2018-04-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-65 years old
• Body weight >110 lbs
• Hemoglobin >12.5 g/dL

You may not qualify if…

• Ineligible for donation based on the New York Blood Center blood donor questionnaire
• Systolic blood pressure >180 or <90 mm Hg, diastolic blood pressure >100 or <50 mm Hg
• Heart rate <50 or >100
• Temperature >99.5 F prior to donation
• Temperature >100.4 F or subjective feeling of illness prior to transfusion (this is to avoid having a concurrent illness affect post-transfusion measurements);
• Positive results on standard blood donor infectious disease testing
• Positive urine pregnancy test

Where it is running

• Columbia University Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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