Red Cell Transfusion Goals in Patients With Acute Leukemias

Completed · Phase 1

Conditions studied: Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia (ALL), Acute Myelogenous Leukemia (AML), Acute Promyelocytic Leukemia (APL)

In brief

The purpose of this study to determine if a lower hemoglobin transfusion threshold, 7 g/dL, has a safety profile similar to that of the current standard transfusion threshold of 8 g/dL.

Key facts

Study ID

NCT02086773

Run by

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

People needed

90

Starts

2014-04-01

Expected to finish

2015-09-01

Last updated by the study team

2019-01-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute leukemia patients (AML, ALL, APL, treatment-related myeloid neoplasm, high grade MDS)
• Admitted with plans for inpatient myelosuppressive chemotherapy (with standard of care or protocol regimens)

You may not qualify if…

• Age less than 18 years
• Acute coronary syndrome as defined by active chest pain, dynamic ECG changes, troponin greater than 2.5
• Active blood loss
• Receiving erythropoietin stimulating agents prior to admission
• Chronic Renal Failure in Renal Replacement Therapy
• Documented wish against transfusion for personal or religious beliefs

Where it is running

• The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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