Ultrasound Method to Measure Fibrosis of the Liver in Children

Stopped early · Not applicable

Conditions studied: Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease, HCV Coinfection, HBV, Drug-Induced Liver Injury

In brief

HYPOTHESIS: The investigators hypothesize that sonoelastography (SE) provide accurate quantitative measurements that can be used to stage liver fibrosis in pediatric patients with chronic liver disease. Specific Aims: To measure liver stiffness with sonoelastography in pediatric and adolescents with suspect diffuse liver disease who will undergo nonfocal liver biopsy as part of their routine clinical care.

Key facts

Study ID

NCT02086708

Run by

Massachusetts General Hospital

People needed

24

Starts

2010-06-01

Expected to finish

2015-03-01

Last updated by the study team

2017-02-01

Who can join

Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients scheduled for random liver biopsy for routine staging of liver fibrosis
• Pediatric patients patients (ages 1-21)
• Girls or boys
• Suspected liver disease
• Consent to participate in the study

You may not qualify if…

• Pregnancy
• Acute illness/cognitive impairment resulting in inability to cooperate with ultrasound
• Patients that do not consent to ultrasound guided liver biopsy.
• Contraindications to liver biopsy (e.g. low platelets defined as a platelet count of less than 50,000, and hemophilia/coagulopathy as an INR higher than 1.5.)

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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