T-helper 2 (Th2) Cytokine Responses in Overweight/Obese Subjects

Completed

Conditions studied: Overweight, Obesity

In brief

Cytokines are chemicals that are naturally made by your body. Certain cytokine levels are changed in the blood of patients who develop allergies and/or asthma. Cytokine levels may also be changed in some individuals who are overweight or obese. The purpose of this study is to determine if certain cytokine levels differ based on a person's weight and whether or not they have allergies or asthma. Information gathered in this study will be compared to information gathered from subjects who have participated in another similar study for patients who have allergies and/or asthma.

Key facts

Study ID

NCT02085759

Run by

West Penn Allegheny Health System

People needed

46

Starts

2009-05-01

Last updated by the study team

2014-03-13

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• adults aged 18 to 50 years
• pre-bronchodilator FEV1 > 80% predicted with no evidence of reversibility following administration of bronchodilator
• no history of allergies

You may not qualify if…

• medical history consistent with atopy and/or asthma
• any positive response to allergy skin testing for inhalant allergens (defined as a wheal > 3 mm larger than the negative control)
• a pre-bronchodilator FEV1 < 80% predicted
• > 12% reversibility in FEV1 following administration of a bronchodilator
• any history of significant chronic illness
• history of respiratory infection within the past 2 weeks
• any use of prescription medications other than oral contraceptives or thyroid hormone replacement within the past 2 months
• use of any investigational medication within the past month

Where it is running

• Allegheny General Hospital, Dept. of Allergy, Asthma, & Immunology — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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