V2 Receptor Effects on Fluid Regulation and Performance

Completed · Not applicable · Has a placebo group

Conditions studied: Electrolyte Imbalance, Hyponatremia, Hypernatremia

In brief

This primary aim of this study was to critically assess whether or not sweat water content and sodium concentration were acutely regulated by dynamic changes in antidiuretic hormone (arginine vasopressin or AVP) acting on the Vasopressin 2 receptor (V2R) during exercise. Secondary aims were to evaluate running performance and core temperature to further characterize the role of AVP in the coordinated balance of fluid and temperature homeostasis during exercise. The primary hypothesis was that activation of the V2R in sweat glands would result in water reabsorption and fluid conservation during endurance exercise.

Key facts

Study ID

NCT02084797

Run by

Oakland University

People needed

10

Starts

2011-06-01

Expected to finish

2012-10-01

Last updated by the study team

2016-05-12

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy (no acute or chronic medical conditions or regular prescription medication use), habitual (>50km/week)
• Distance runners between the ages of 18-60 years.

You may not qualify if…

• Individuals with chronic medical problems which require regular prescription medication
• Runners with pre-existing kidney problems
• Unable to sense thirst
• Difficulty swallowing
• Gastrointestinal disorders
• History of fainting associated with blood draw.

Where it is running

• Oakland University — Rochester, Michigan, United States

Full record on ClinicalTrials.gov

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