Evaluation and Treatment Planning of Patients With PAP Using Thrive Ultra Short Echo Time MRI and CT

Completed

Conditions studied: Pulmonary Alveolar Proteinosis

In brief

The purpose of this study is twofold: to assess routine cat scan (CT) imaging as a biomarker for removal of lipoprotein surfactant via lung lavage (where CT is the gold-standard imaging technique for density quantification), and to utilize a novel UTE MRI protocol to similarly quantify surfactant removal. This study will also serve to generate baseline scanning that may aid in developing analytical tools to evaluate and treat specific lung regions of patients with PAP.

Key facts

Study ID

NCT02081092

Run by

Children's Hospital Medical Center, Cincinnati

People needed

9

Starts

2013-12-01

Expected to finish

2018-10-29

Last updated by the study team

2018-11-01

Who can join

Age: 8 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically diagnosed PAP scheduled for lung lavage with double lumen endoscopy.
• Children patients ≥ 8 years of age
• Adult patients ≤ 75 years of age
• Medically stable as per the opinion of Bruce Trapnell, MD or Robert Wood, MD
• Patient and or parent consent obtained

You may not qualify if…

• Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology
• Pregnancy

Where it is running

• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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