Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse

Completed · Phase 2 · Has a placebo group

Conditions studied: Cocaine Dependence

In brief

This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.

Key facts

Study ID

NCT02080819

Run by

Virginia Commonwealth University

People needed

131

Starts

2014-02-01

Expected to finish

2017-01-21

Last updated by the study team

2018-04-12

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and female subjects
• Age 18 to 50
• Meet current DSM-IV criteria for cocaine dependence who are seeking treatment.

You may not qualify if…

• Current DSM-IV diagnosis of any psychoactive substance dependence other than cocaine, marijuana, nicotine, or alcohol
• Have a DSM-IV axis I psychiatric disorder or neurological disease or disorder requiring ongoing treatment and/or making study participation unsafe
• Significant current suicidal or homicidal ideation
• Medical conditions contraindicating levodopa/carbidopa or pharmacotherapy (e.g., evidence of any movement disorder, clinically significant pulmonary disease, cardiovascular disease, liver or kidney disease, seizure disorder)
• Taking CNS active concomitant medications
• Taking medications known to have significant drug interactions with the study medication (e.g., CYP P-450-2D6 inhibitors, such as tamoxifen, iron salts, pyridoxine, monoamine oxidase inhibitors, phenothiazines, selegiline, anesthetics)
• Having conditions of probation or parole requiring reports of drug use to officers of the court
• Impending incarceration
• Pregnant or breast feeding for female patients
• Inability to read, write, or speak English
• Having plans to leave the immediate geographical area within 3 months
• Unwillingness or not competent to sign a written informed consent form
• Individuals who have pacemakers, metal or electromechanical implants or metallic foreign bodies
• Patients who are known to be HIV positive will not be included due to possible CNS effects of HIV.
• Alcohol withdrawal symptoms or history of significant previous alcohol withdrawal symptoms

Where it is running

• Virginia Commonwealth University — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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