Tranexamic Acid in Orthopaedic Trauma Surgery
Status unconfirmed · Not applicable
Conditions studied: Blood Loss, Trauma, Fracture, Surgery
In brief
Tranexamic acid is an antifibrinolytic drug that has been used to decrease post-operative blood loss. This study is a prospective, randomized controlled trial investigating the use of tranexamic acid in fracture surgery around the hip and knee, in which significant blood loss (\>300mL) is expected. The hypothesis of this study is that tranexamic acid will be associated with a decrease in post-operative blood loss, as well as a decreased need for allogenic blood transfusion, in patients who have fracture surgery around the hip and knee.
Key facts
- Study ID
- NCT02080494
- Run by
- University of Tennessee
- People needed
- 101
- Starts
- 2012-05-01
- Expected to finish
- 2018-12-01
- Last updated by the study team
- 2018-07-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with isolated fractures of the pelvic ring, acetabulum, femur or tibia that will require open reduction and internal fixation
- Expected blood loss is greater than 300 mL
- Age ≥ 18
- Skeletal maturity
You may not qualify if…
- Pregnant or breastfeeding
- Patients taking oral contraceptives
- Contraindication to venous thromboembolic event (VTE) prophylaxis (intracranial, intrathoracic, intra-abdominal bleeding or spine fractures)
- Patients requiring operative intervention for other injuries (orthopaedic or non-orthopaedic)
- Known hypercoagulable state including history of prescribed anti-coagulation (warfarin, plavix, low molecular weight heparin)
- Renal Insufficiency (creatinine greater than 1.5mg/dL)
- Open fractures
Where it is running
- Erlanger Health System — Chattanooga, Tennessee, United States
Full record on ClinicalTrials.gov
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