Effect of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases
Completed · Not applicable
Conditions studied: Major Depressive Disorder
In brief
The purpose of this study is to determine whether upregulating the left amygdala during positive autobiographical memory recall via real time functional magnetic resonance imaging neurofeedback will lead to an improvement in clinician administered ratings of depressive symptoms. The investigators predict that patients with major depressive disorder receiving left amygdala neurofeedback will increase their amygdala response during positive autobiographical memory recall compared to those receiving control feedback from a region not involved in emotional processing and that this ability will be associated with clinically significant improvement.
Key facts
- Study ID
- NCT02079610
- Run by
- Laureate Institute for Brain Research, Inc.
- People needed
- 36
- Starts
- 2014-04-01
- Expected to finish
- 2016-04-01
- Last updated by the study team
- 2017-09-25
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- clinical diagnosis of major depressive disorder
- right handed
- adult aged 18-55
- currently depressed
You may not qualify if…
- clinically significant or unstable cardiovascular, pulmonary, endocrine, neurological, gastrointestinal illness or unstable medical disorder
- met Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for alcohol and/or substance abuse or substance dependence (other than nicotine) within 12 months prior to screening
- endorse suicidal intent or have made a suicide attempt within the preceding three months
- history of traumatic brain injury
- inability to complete MRI scan due to claustrophobia or general MRI exclusions (e.g., shrapnel inside body)
- current pregnancy or breast feeding
- a primary language other than English
- received psychotropic drugs for at least 3 weeks (8 weeks for fluoxetine) prior to scanning (Effective medications will not be discontinued for the purposes of the study)
Where it is running
- Laureate Institute for Brain Research — Tulsa, Oklahoma, United States
Full record on ClinicalTrials.gov
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