Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant

Completed · Not applicable

Conditions studied: Cancer Survivor, Diabetes Mellitus, Hypertension

In brief

This pilot clinical trial studies computed tomography (CT) scans and biomarker analysis in diagnosing coronary artery disease (CAD) in patients who have undergone a stem cell transplant but have no symptoms of CAD. CAD is a disease in which there is a narrowing or blockage of the coronary arteries (blood vessels that carry blood and oxygen to the heart) and patients who have undergone a stem cell transplant are at an especially high risk for CAD. A CT scan involves a series of detailed pictures of areas inside the body taken from different angles. The pictures are created by a computer linked to an x-ray machine. Studying samples of blood from patients who have undergone a stem cell transplant in the laboratory may help doctors identify and learn more about biomarkers related to CAD. Using a CT scan in combination with biomarker analysis may be a better and less-invasive way to diagnose CAD.

Key facts

Study ID

NCT02077218

Run by

City of Hope Medical Center

People needed

20

Starts

2014-02-01

Expected to finish

2015-04-01

Last updated by the study team

2015-04-21

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Alive and in complete remission at time of enrollment
• Underwent allogeneic HCT after 1995
• Time between HCT and study entry: >= 2 years
• Have at least one CVRF (hypertension, diabetes, dyslipidemia) at the time of eligibility determination

You may not qualify if…

• History of ischemic heart disease, stroke, or cardiomyopathy/congestive heart failure
• Abnormal renal function (glomerular filtration rate [GFR] < 60 mL/min/1.73m2)
• Pregnancy
• Known allergy to intravenous (IV) contrast
• Sustained or symptomatic ventricular dysrhythmias uncontrolled with drug therapy or implantable device; significant conduction defects (i.e.: second or third degree atrioventricular block or sick sinus syndrome)
• Current clinical evidence of moderate-to-severe obstructive pulmonary disease or reactive airway diseases (i.e.: asthma) requiring therapy
• History of drug sensitivity or allergic reaction to beta-blockers
• Currently taking calcium channel blockers such as verapramil and diltiazem
• History of unrepaired severe aortic stenosis

Where it is running

• City of Hope Medical Center — Duarte, California, United States

Full record on ClinicalTrials.gov

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