Cholinergic Nicotinic Receptors and Cognition in PD
Completed
Conditions studied: Parkinson's Disease
In brief
Mild cognitive impairment and dementia are frequent non-motor complications of moderate to advanced Parkinson's disease. Brain positron emission tomography (PET) study findings confirm post-mortem evidence that cholinergic loss is related to cognitive impairment in Parkinson's disease. However, current cholinergic augmentation therapy is not always effective and it should only target those Parkinson's disease patients who have evidence of cholinergic system impairment. The objective of this study is to study the association of a particular subtype of cholinergic receptors, so-called nicotinic acetylcholine receptors, with cognition in Parkinson's disease using a novel PET marker of cholinergic system integrity.
Key facts
- Study ID
- NCT02076295
- Run by
- University of Michigan
- People needed
- 48
- Starts
- 2014-02-01
- Expected to finish
- 2016-12-30
- Last updated by the study team
- 2017-04-17
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- PD subjects (M/F, non-smoking, ≥ 50 years old, Hoehn \& Yahr stages 1-4)
- Normal control subjects (N=15, M/F, non-smoking, ≥ 50 years old)
You may not qualify if…
- Active smoking, use of other tobacco products, or use of nicotinic drugs such as nicotine patches or varenicline.
- Subjects with contra-indications to MR imaging, including pacemakers or claustrophobia.
- Evidence of large vessel stroke or mass lesion on MRI.
- Use of (anti-)cholinergic or neuroleptic drugs.
- Dementia or severe cognitive impairment confirmed by clinical and detailed neuropsychological assessment precluding safe study participation, performing study procedures, or unable to follow directions by study personnel.
- Evidence of atypical parkinsonism on neurological exam.
- Subjects limited by participation in research procedures involving ionizing radiation.
- Pregnancy (test within 48 hours of each PET session) or breastfeeding
Where it is running
- University of Michigan Health System — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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