Comparison of Transbronchial, Cryoprobe, and VATS Biopsy for the Diagnosis of Interstitial Lung Disease

Completed · Not applicable

Conditions studied: Interstitial Lung Disease

In brief

The objective of this study is to compare the sample size, architectural preservation and diagnostic yield of bronchoscopic cryo-probe transbronchial lung biopsy (C-TBBx) in comparison to bronchoscopic standard transbronchial lung biopsy (S-TBBx) and Video-Assisted Thoracoscopic Surgery (VATS) lung biopsy for the diagnosis of interstitial lung disease (ILD).

Key facts

Study ID

NCT02075762

Run by

Johns Hopkins University

People needed

15

Starts

2013-08-01

Expected to finish

2018-12-01

Last updated by the study team

2019-01-18

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Older than 18 years of age
• Scheduled VATS biopsy for suspected ILD as part of standard medical care
• Negative pregnancy test
• Mentally capable of understanding study procedures

You may not qualify if…

• A disease or condition that interferes with safe completion of the study including:
• Platelet count < 50,000 Coagulopathy defined as an International
• Normalized Ratio (INR) > 1.5, or discontinuation of ticagrelor or clopidogrel within 5 days of procedure.
• Hemodynamic instability with systolic blood pressure <90 mmHg or heart rate > 120 beats/min, unless deemed to be stable with these values by the surgical or interventional pulmonary attending physicians
• Hypoxemia with pulse oximetry values <88% or partial pressure of oxygen in arterial blood (PaO2) < 60 on baseline oxygen requirements
• Concurrent participation in another study involving investigational drugs or investigational medical devices

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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