Effect of Blueberry Consumption on Metabolic Syndrome & DNA Damage
Completed · Not applicable · Has a placebo group
Conditions studied: Metabolic Syndrome, Insulin Resistance, DNA Damage
In brief
Obesity usually brings with it disturbances in the body that increase the chances of developing serious diseases like diabetes and cancer. These disturbances include one or more symptoms of a condition called "metabolic syndrome" that often leads to diabetes. High levels of damage to the DNA that makes up our chromosomes have also been observed in obese people. It is possible that these two disturbances are connected. The goal of this project is to test this whether consumption of blueberries will improve these abnormalities.
Key facts
- Study ID
- NCT02075307
- Run by
- UCSF Benioff Children's Hospital Oakland
- People needed
- 7
- Starts
- 2014-01-01
- Expected to finish
- 2017-04-04
- Last updated by the study team
- 2020-12-23
Who can join
Age: 30 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 30-60 years;
- BMI > 30;
- Blood pressure <140/90 mmHg without antihypertensive medicines or with a stable dose of antihypertensive medicines (no change in last 3 months).;
- Insulin resistance (HOMA/IR) > 2.0;
- Willing to restrict intake of high polyphenol-containing foods during the trial period;
- Willing to forego intake of nutritional supplements other than a multivitamin;
- Willing to maintain their current daily level of exercise throughout the study.
You may not qualify if…
- Known diabetes mellitus according to the 2013 ADA criteria;
- Medications known to affect glucose metabolism;
- Weight loss pharmacotherapy;
- Lipid-lowering medication;
- Untreated thyroid or chronic liver, renal, or cardiovascular disease;
- Smoking;
- Pregnancy- a negative urine pregnancy test will be documented for any women participants of childbearing age prior to enrollment.
- History of allergic reactions to blueberries.
- Any pathological condition known to alter white blood cell count over the previous 6 months;
- Exposure to drugs known to cause mutations or radiation within the previous 6 months;
- Alcohol consumption greater than 2 drinks/d for males and 1 drink/d for females.
Where it is running
- Children's Hospital & Research Center Oakland — Oakland, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.