A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody

Completed · Phase 2/Phase 3

Conditions studied: Hemophagocytic Lymphohistiocytosis

In brief

International, multicenter, long-term, follow-up study that will enrol HLH participants who have received emapalumab in previous clinical trials, in the context of the clinical development program for emapalumab or under compassionate use (CU).

Key facts

Study ID

NCT02069899

Run by

Swedish Orphan Biovitrum

People needed

58

Starts

2014-08-04

Expected to finish

2021-05-18

Last updated by the study team

2022-06-28

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Having received at least one dose of emapalumab.
• Having signed the Informed Consent by the participant or the participant's legal representative(s), as applicable, with the assent of participant who are legally capable of providing it.

You may not qualify if…

• None

Where it is running

• Spectrum Health Helen Devos Children's Hospital — Grand Rapids, Michigan, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Cincinnati Children's Hospital - Division of Immunobiology — Cincinnati, Ohio, United States
• Cincinnati Children's Hospital — Cincinnati, Ohio, United States
• Texas Children's Cancer Center — Houston, Texas, United States
• Hôpital Necker-Enfants Malades — Paris, France
• Fondazione MBBM c/o Ospedale San Gerardo Clinica Pediatrica — Monza, Italy
• Azienda Ospedaliera Padova — Padova, Italy
• Ospedale Pediatrico Bambino Gesu - UO Reumatologia — Rome, Italy
• Ospedale Pediatrico Bambino Gesu — Rome, Italy
• Ospedale della Donna e del Bambino - U.O.C. Oncoematologia Pediatrica — Verona, Italy
• Hospital Universitario Vall d'Hebron Servei de Hematologia i Oncologia — Barcelona, Spain
• Sant Joan de Déu Hospital - Pediatric Rheumatology Department — Barcelona, Spain
• Hospital Universitario Niño Jesús Servicio de Hemato-Oncología Pediátrica — Madrid, Spain
• UCL Institute of Child Health Great Ormond Street Hospital — London, United Kingdom
• Great Ormond Street Hospital - Department of Haematology — London, United Kingdom

Full record on ClinicalTrials.gov

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